Sure! A trip to Cairo and Sharm El-Sheikh will be a perfect blend of history, culture and relaxation. Here are some travel tips to ensure your journey is smooth:

Best Time to Visit:
The best time to visit Cairo is from October to April when temperatures are at their most pleasant. Sharm El-Sheikh, being a coastal city, experiences pleasant weather during the same months but can also be visited during the summer for water-based activities.

Route and Accessibility:
International flights operate directly to both Cairo and Sharm El-Sheikh. Once in Egypt, internal flights or coach buses are available for travel between the two cities.

Altitude and Acclimatization:
Altitude won’t be an issue as both cities are relatively at sea level. Acclimatization will involve adjusting to the hot climate, especially if you're visiting in summer.

Accommodation and Booking:
Both cities offer numerous accommodation options ranging from luxury resorts to budget hostels. It's recommended to book your accommodation in advance to secure better prices and availability.

Clothing and Essentials:
Despite the hot weather, it is respectful to dress modestly in Egypt. Light, airy, and loose-fitting clothes are recommended, but women especially should avoid wearing too short or tight outfits, out of respect for the local culture. In Sharm el-Sheikh, on the beach, usual western beach attire is fine. Don’t forget your sunglasses, wide-brimmed hat, and sunscreen!

Health and Safety:
Drink lots of water to avoid dehydration due to high temperatures. Ensure your travel insurance covers medical expenses. In terms of safety, both cities are generally safe, but it's always wise to be aware of your surroundings and avoid deserted areas at night.

Local Etiquette and Respect:
Egyptians are known for their hospitality. Always be respectful of their customs and traditions. It's also customary to tip for services. While visiting religious sites, dress modestly and follow site rules.