Definitely! Annecy, Grenoble, and Chambéry form a wonderful trio of cities to visit in France's southeastern Alps region. Here's what you should keep in mind:

Best Time to Visit:
Summers (June-August) and winters (December-March) can be excellent, depending on what you prefer. Summer offers comfortable weather for exploring the cities and their surroundings while winter allows for enjoying winter sports in Grenoble.

Route and Accessibility:
Flying into Geneva or Lyon and then renting a car or taking a train/buses can be the most efficient way to reach these cities. They are all interconnected by well-maintained motorways and train routes.

Altitude and Acclimatization:
While these cities aren't at very high altitudes, if you plan to venture into the surrounding Alps, remember to take it easy while adjusting to the higher altitudes.

Accommodation and Booking:
Booking in advance is recommended, especially in high tourist seasons (summer and winter holidays). Each of these cities has a range of options from budget to luxury accommodations.

Clothing and Essentials:
In summer, comfortable walking shoes, sunscreen, and light clothing with a raincoat for sudden showers are recommended. For winter, pack warm and waterproof clothing, especially if you plan to ski or snowboard.

Health and Safety:
Ensure you have comprehensive medical insurance. If participating in outdoor activities, remember to follow any safety instructions/guidelines provided by activity organizers.

Local Etiquette and Respect:
French people appreciate it when you try to speak their language, so learning a few basic phrases in French would be useful. Bear in mind it is customary in France to greet people with a simple "Bonjour" (good day) or "Bonsoir" (good evening), and "Merci" (thank you) is always appreciated.