Sure, visiting Berlin, Leipzig, Munich, and Dresden in Germany is a fantastic plan! Here are some travel tips for your journey:

Best Time to Visit:
For the most pleasant weather, visit between May and September. Christmas season (late November to December end) is also a fantastic time to experience the German Christmas markets.

Route and Accessibility:
Germany has an excellent public transportation system. Inter-city travel can easily be done by train or bus. Berlin and Munich have international airports, while Leipzig and Dresden have smaller domestic airports. You could start your trip from either Berlin or Munich.

Altitude and Acclimatization:
Being major cities, none of these places have high altitude issues, hence, acclimatization would not be needed.

Accommodation and Booking:
All four cities have a variety of accommodation options, from luxury hotels to budget hostels. It's recommended to book in advance, especially during peak tourist seasons.

Clothing and Essentials:
Germany's weather can often be unpredictable. Pack a variety of clothing, including a lightweight rain jacket. Make sure to carry a comfortable pair of shoes as exploring German cities involves quite a bit of walking.

Health and Safety:
Europe and Germany are generally safe to travel to. However, it's suggested to have travel insurance. Also, carry important medicines and adhere to the covid-19 guidelines as set by the local government.

Local Etiquette and Respect:
Germans are particular about punctuality, so ensure being on time for any tours or appointments. Respect all local laws and customs. When visiting churches, dress modestly.

Remember to try the local cuisine, visit historical sites, and enjoy the local culture and hospitality in each city. Have a great trip!