Definitely! Egypt is a fascinating destination with its rich history and culture. Here's some useful information for a smooth journey:

Best Time to Visit:
The best time to visit Cairo, Luxor, and Aswan is during the cooler months, from October to April. Although the South (Luxor and Aswan) doesn't get as cold as Cairo, temperatures in all these cities are much more comfortable compared to the sweltering summer months.

Route and Accessibility:
Cairo, Luxor, and Aswan are well connected by air, road and rail. Most people fly into Cairo, Egypt's capital, from where you can take domestic flights or overnight trains to Luxor and Aswan. Nile cruises are a popular way of visiting Luxor and Aswan, offering a mix of comfort and sightseeing.

Altitude and Acclimatization:
These cities are at low altitudes, so acclimatization isn't generally a concern. However, noting the harsh sun and heat during summers, it's necessary to stay hydrated.

Accommodation and Booking:
Egypt offers a wide range of accommodations, from luxury hotels to budget hostels. As these cities are major tourist destinations, it's recommended to book in advance. In Cairo, the areas around the Nile Corniche and Zamalek are popular, while in Luxor and Aswan, accommodations offering a Nile-view are favored.

Clothing and Essentials:
In respect to the predominantly Muslim culture, it's advisable to dress modestly. Carry light clothes but also cover-ups for visiting religious sites. Include essentials like a hat, sunblock, and sunglasses to protect against the sun. Remember to carry a universal adapter for your electronics.

Health and Safety:
Stick to bottled water and avoid raw or undercooked food to prevent stomach upsets. The sun can be intense, so protect yourself and stay hydrated. Take out travel insurance that covers medical expenses.

Local Etiquette and Respect:
Respect the local culture and traditions. Egyptians are warm and friendly, but conservatively dressed. Avoid controversial topics of discussion. Also, tipping (baksheesh) is customary in Egypt for services rendered.