Absolutely! Here's how you can make your visit to Cape Town, Johannesburg, and Durban, South Africa safe and enjoyable:

Best Time to Visit:
The best time to visit these cities is in their summer months between November and February when the weather is warm and sunny.

Route and Accessibility:
All three cities are well connected by road and rail. Cape Town and Johannesburg have international airports; Durban has a domestic one. For intercity travel, consider domestic flights, as the distance between these cities is considerable.

Altitude and Acclimatization:
Johannesburg is at a high altitude, but altitude sickness is uncommon. Cape Town and Durban are at sea level so there won't be any altitude issues.

Accommodation and Booking:
Book your accommodations in advance, there is a variety of accommodations ranging from luxury hotels to budget guesthouses.

Clothing and Essentials:
Pack lightweight clothing for the day and a jacket or sweater for chillier evenings. Always carry sunblock as the African sun can be harsh. Swimming gear is a great addition if you're visiting Durban's beaches.

Health and Safety:
Standard vaccinations like Hepatitis A and B, typhoid, cholera, yellow fever, and rabies are recommended. Be cautious of your belongings and avoid isolated areas at night.

Local Etiquette and Respect:
South Africans are generally relaxed and friendly. Respect the diverse cultures and traditions. Public smoking is banned in South Africa and it is customary to tip 10-15% in restaurants.

Remember:
Crime can be an issue in South Africa, particularly in Johannesburg. Stay vigilant, avoid flashy displays of wealth, and be cautious in less populated areas.