Hello! That sounds like an exciting trip to Italy covering Florence, Venice and Milan. Here are some travel tips for you.

Best Time to Visit:
The best time to visit these Italian cities is from April to June, and September to October when the weather is usually comfortable. July and August can be hot and crowded.

Route and Accessibility:
All three cities are well-connected by the Italian rail system, Trenitalia. Start your journey from Florence, then move to Venice, and finally to Milan. You can also opt for flights or buses, but the train network is affordable and efficient.

Accommodation and Booking:
There are plenty of hotels and vacation rentals available in all these cities. It is advised to book your accommodation well in advance, and centrally located places are preferable for easy access to major attractions.

Clothing and Essentials:
Pack light, breathable clothing for summer months, and warm clothes for winters along with comfortable walking shoes. Also, don’t forget to pack a good quality sunblock, a travel adapter for your electronics, and an umbrella.

Health and Safety:
Overall, Italy is a safe destination but watch out for petty thieves, especially in crowded tourist spots. Be updated with travel advisories and maintain a travel insurance. Keep emergency contacts handy and follow Covid-19 safety protocol.

Local Etiquette and Respect:
Italians are generally warm and welcoming. Respect local customs, don’t speak loudly in public places, dress modestly when visiting churches and always say 'Please' (Per Favore) and 'Thank You' (Grazie).