Hello! It sounds like you are embarking on an exciting trip to the Netherlands, specifically Enschede, Nijmegen, and Arnhem! Here are some travel tips to assist you in your journey.

Best Time to Visit:
The best times to visit these cities in the Netherlands are from April to October. During these months, the weather is warmer and drier, and there are numerous outdoor festivals and events happening.

Route and Accessibility:
These cities are easily accessible by train or car from Amsterdam Airport Schiphol. Enschede is about 2 hours by train, Nijmegen is about an hour and a half, and Arnhem is slightly over an hour. Inter-city travel is also convenient thanks to the Netherlands' excellent public transportation system.

Accommodation and Booking:
There are various accommodation options in all these cities ranging from high-end hotels to budget hostels. Booking.com, Expedia, and TripAdvisor are commonly used to compare prices and book accommodations. It is advisable to book your accommodations in advance, especially if you are visiting during the busy tourist season.

Clothing and Essentials:
The weather can be unpredictable, so packing layers is advised. Bring a waterproof coat for rain showers. Don't forget your comfortable shoes for walking, a hat and sunblock for the summer, and scarves and gloves if you are visiting in the colder months. A power adapter is also essential as the Netherlands uses Type C and Type F plugs.

Health and Safety:
The Netherlands is a generally safe country, but it is still important to take precautions like keeping your belongings secure and maintaining awareness of your surroundings. A travel insurance policy to cover theft, loss and medical problems is also recommended.

Local Etiquette and Respect:
Dutch people value punctuality. Tipping is customary in restaurants, with a usual amount of around 10% for good service. Also, Dutch people appreciate polite conversation and respect for personal space.