Absolutely! A visit to Charleston, Savannah, and New Orleans offers vibrant culture, historic charm, and rich culinary scenes. Here are some travel tips for your journey:

Best Time to Visit:
The ideal time to visit Charleston is March through June when the temperatures are mild.
For Savannah, the best time is March to July with the vibrancy of spring celebrations.
New Orleans is best visited between February and May when the weather is comfortably cool and the celebrations are in full swing.

Route and Accessibility:
All three cities are well connected. While Charleston and Savannah are best explored by foot or local transportation, in New Orleans, the Streetcars are an efficient and scenic way to get around.

Altitude and Acclimatization:
These cities are at sea level, so there are no concerns about altitude sickness. However, do consider the humidity level in these areas, which can get very high, especially during summer.

Accommodation and Booking:
All three cities offer a variety of accommodations ranging from luxury hotels to retreats and B&Bs. It's recommended to book in advance for the best selection, particularly if you're visiting during Mardi Gras in New Orleans.

Clothing and Essentials:
Pack clothing appropriate for the season. Don’t forget comfortable shoes for walking. An umbrella or raincoat may also be useful, as sudden showers are common. Also, carry sun protection items.

Health and Safety:
Carry mosquito repellent, particularly for the summer months in these cities. Although these cities are generally safe for tourists, it's always wise to be cautious and avoid less crowded areas late at night.

Local Etiquette and Respect:
All three cities have a rich history and culture. Respect local traditions, customs, and heritage sites. In New Orleans, remember to be respectful of performers on the street - if you stop to watch, always tip.
Enjoy the flavours of the South, but be aware of your noise levels to respect the residential peace, particularly in tightly-packed city centers.