Absolutely! Your journey through Northern England will be exciting and incredibly diverse. Here are some travel tips for visiting Liverpool, Manchester, Leeds, and York:

Best Time to Visit:
The best times to visit these cities are during the spring (April to June) and autumn (September to November). The weather is generally pleasant in these periods, making them ideal for outdoor activities.

Route and Accessibility:
Trains connect all these cities and are the most convenient and quick mode of transport. The train journey between each city is around 1-2 hours.

Altitude and Acclimatization:
These cities are located in lower altitudes, so there's no need for special acclimatization.

Accommodation and Booking:
There are a plethora of accommodation choices in these cities - from luxury hotels to hostels and BnBs. It's recommended to book your accommodations in advance for better deals and availability.

Clothing and Essentials:
Pack according to the weather. The UK is known for its unpredictable weather, so it's wise to carry a compact umbrella and rainproof jacket. Comfortable walking shoes are a must for city tours.

Health and Safety:
Take note of the location of nearby hospitals and pharmacies. Also, ensure you have travel insurance that will cover any potential health issues.

Local Etiquette and Respect:
While visiting any historical or religious sites, ensure you follow the local etiquettes. In general, British people appreciate politeness and respect for their traditions and cultures.