Sure, here are some tips for your trip to the beautiful cities of Cyprus:

Best Time to Visit:
The best time to visit Paphos, Limassol, Larnaca, and Famagusta is from March until May (Spring) or from September until November (Autumn) because the weather is more gentle and it's not that crowded like in Summer.

Route and Accessibility:
The main international airports in Cyprus are in Larnaca and Paphos. Both cities are good starting points for your travels. Roads in Cyprus are well-maintained and car rentals are readily available for easier movement between the cities.

Altitude and Acclimatization:
These Cypriot cities are at sea level, so altitude sickness is not a concern. Just make sure to stay hydrated, especially during the hotter months.

Accommodation and Booking:
Accommodation options range from luxury resorts to quaint guesthouses, it's advisable to book ahead of time especially during peak tourist season.

Clothing and Essentials:
Pack lightweight and breathable clothing for the day, and a light sweater, as evenings can be cooler. Don't forget your swimsuit, sunblock, hat, sunglasses, and comfortable walking shoes.

Health and Safety:
No specific vaccinations are required for Cyprus. However, basic health precautions like travel insurance, routine vaccines are recommended. Also, don't forget your personal medicine.

Local Etiquette and Respect:
In Cyprus, people have a laid-back, polite, and respectful manner. Dress code is mostly casual, but modest attire is recommended when visiting religious places. Always check if photography is permitted before taking pictures, particularly in sacred or historical sites. In conversation, avoid sensitive subjects like the island's political situation.

Remember to try the local food and wine, visit archaeological sites like Kourion and the Tomb of the Kings, explore beautiful beaches and enjoy your journey.