Absolutely! Traveling through Germany's vibrant cities will be a fantastic experience. Here are some tips to make your journey smooth and enjoyable:

Best Time to Visit:
The best time to visit these cities is typically from May through September when the weather is pleasantly warm. The Christmas markets in December are also a popular time to visit.

Route and Accessibility:
All of these cities are well-connected by rail and road. Use the Deutsche Bahn for easy and efficient train travel between cities. Taking a drive could allow you to explore smaller towns and countryside en route.

Altitude and Acclimatization:
These cities are at a low elevation, so altitude sickness won't be an issue. However, do adjust to the time difference if you're traveling from afar.

Accommodation and Booking:
Booking your accommodations in advance is advisable. There's a wide range of options from luxury hotels to budget hostels. Consider staying in city centre areas for easy access to attractions.

Clothing and Essentials:
Weather can be changeable in Germany, so layered clothing is ideal. Comfortable walking shoes are a must for city exploration. Carry an umbrella or a raincoat as well.

Health and Safety:
Germany is known for its safety and efficient healthcare. Make sure your health insurance covers your stay. Be mindful of the Covid-19 protocols as advised by the authorities.

Local Etiquette and Respect:
Germans value punctuality and etiquettes. Be courteous, respect public rules. Tipping is customary in restaurants and bars. Try to learn a few basic phrases in German - it's appreciated by locals.