Absolutely, here's the travel guide for your trip to Perth, Albany, and Esperance in Australia:

Best Time to Visit:
The best time to visit Perth, Albany, and Esperance is from September to November during the spring season. The weather is pleasant and ideal for sightseeing.

Route and Accessibility:
Direct flights from major cities around the globe are well connected to Perth.
From Perth, you can drive to Albany, it will take you around 5 hours.
The coastal route to Esperance from Albany is a 482 km long beautiful drive which you can plan as a day's trip.

Altitude and Acclimatization:
Perth, Albany, and Esperance reside at sea level so altitude acclimatization isn't necessary.

Accommodation and Booking:
Both Albany and Esperance have a range of accommodations including luxury resorts, hostels, and more budget-oriented options like motels and caravan parks. It is advisable to book your accommodation well in advance, particularly if visiting during peak season.

Clothing and Essentials:
Depending on the season of your visit, pack appropriate clothing. During spring, light clothing for the day and a light jacket for evening is appropriate.
Always carry sun protection (sunscreen, hat, sunglasses) considering Australian high UV index, and an insect repellent can be handy as well.

Health and Safety:
Australia has a high standard of healthcare. However, ensure that you have comprehensive travel insurance that covers health.
Be aware of your surroundings and follow local guidance, particularly when visiting beaches and while snorkelling or diving. Be mindful of the presence of poisonous creatures in the sea and on land.

Local Etiquette and Respect:
Australians are generally hardy and hospitable. Common courtesy and respect for local customs and traditions are appreciated. Keep in mind this is a diverse country with many cultures represented, so be considerate and respectful of that fact.