Sure! Visiting Toronto, Hamilton, and Kingston is a great opportunity to experience some of the best attractions in Canada.

Best Time to Visit:
The best time to visit Toronto, Hamilton, and Kingston are during the spring (April-June) or fall (September-October). These seasons offer mild temperatures and less crowded tourist spots. Summer (July-August) is another option if you don't mind the higher temperatures and peak tourist season.

Route and Accessibility:
Toronto, Hamilton, and Kingston are all cities located in Ontario. Road Infrastructure is excellent, with highways connecting all three cities. The drive from Toronto to Hamilton is about an hour, and from Hamilton to Kingston, it's approximately 2.5 to 3 hours. Public transport like buses and trains also connect these cities.

Altitude and Acclimatization:
These cities are all at low altitudes, so there's no need to worry about acclimatizing to the altitude.

Accommodation and Booking:
Accommodation options in all three cities range from budget hotels to luxury resorts. It's always advisable to book your hotel in advance, especially during the peak tourist season. Airbnb is also a popular option in Canada.

Clothing and Essentials:
The weather can be unpredictable, so pack a mix of light and warm clothing. Don't forget a good pair of walking shoes, sunglasses, a hat, and sunscreen.

Health and Safety:
Canada has one of the highest standards of health care in the world. But travel insurance that covers health, accident, and loss/theft of personal effects is recommended.

Local Etiquette and Respect:
Canadians are polite and courteous. The standard greeting is a firm handshake. Tipping is customary in restaurants, bars, and taxis. The usual amount is 15-20% of the total bill. When visiting places of cultural and historical significance, be respectful.