Absolutely! Strasbourg, Colmar and Reims are beautiful cities full of history and charm. Here are some helpful travel tips for your journey:

Best Time to Visit:
The best time to visit these cities would be spring (April to June) or fall (September to October) when the weather is at its most pleasant. If you want to experience the famous Christmas markets, December would be ideal.

Route and Accessibility:
The cities are well connected by train. The fastest way to travel to Strasbourg or Colmar from Paris is by TGV train, and the journey takes a little over 2 hours. From Strasbourg to Colmar, it's only 30 minutes by train. Reims can be reached from Paris in about 45 minutes by TGV.

Altitude and Acclimatization:
There should not be any worries about altitude and acclimatization as these cities are all at low altitudes.

Accommodation and Booking:
Accommodation options in these cities range from hostels to luxury hotels. It's advisable to book well in advance, especially during peak season and around Christmas time.

Clothing and Essentials:
In spring or fall, pack lightweight clothing with a few warmer layers for cooler mornings and evenings. Comfortable walking shoes are a must. During winter, warm clothing – gloves, scarfs and hats – are recommended.

Health and Safety:
These cities are generally quite safe, but as with anywhere, take usual precautions to guard against pickpockets, especially in crowded tourist areas.

Local Etiquette and Respect:
These cities harbor centuries-old traditions and customs. It's appreciated if visitors are respectful. When visiting any religious sites, remember to dress modestly and behave respectfully.