Absolutely! These are some of the most beautiful places to visit in South Africa.

Best Time to Visit:
The best time to visit Krugersdorp and Addo is from November to April, which is summer in South Africa. Cape Town is lovely almost all year round but if you want to avoid the peak tourist season, you could visit during the months of March to May or September to November.

Route and Accessibility:
To get to Kruger, you would likely fly into O.R. Tambo International Airport in Johannesburg, and then choose between a domestic flight, guided tour, or self-drive. Addo Elephant National Park is roughly an hour's drive from Port Elizabeth. Cape Town is well connected by flights from any major cities.

Altitude and Acclimatization:
Altitude isn't a significant issue in these areas, as they are not particularly high.

Accommodation and Booking:
There's a range of accommodation options in all of these places, from luxury resorts to budget guesthouses. Remember to book in advance, especially if you're traveling during the South African school holidays.

Clothing and Essentials:
Pack comfortable, light clothing and a good pair of walking shoes for Krugersdorp and Addo. For Cape Town, you may need a light jacket for the evenings. Always have a hat, sunscreen and sunglasses due to the strong African sun.

Health and Safety:
It's safe to travel to these destinations, but it's always wise to stay alert and keep your valuables secure. As for health precautions, make sure you're up-to-date on routine vaccines, and make sure to carry any prescribed medications.

Local Etiquette and Respect:
South Africans are generally friendly and respectful. An understanding of the local culture could further enrich your trip. Always ask permission before photographing people. When visiting nature reserves, remember to respect the wildlife and maintain a safe distance.