Absolutely! Your trip through South Africa's Western and Eastern Cape is sure to be an adventure. Here are some important tips for your journey:

Best Time to Visit:
October to March is the ideal time to visit these areas, as the weather will be warm and you would be able to fully enjoy the beaches of Port Elizabeth and Cape Town.

Route and Accessibility:
Starting from Port Elizabeth, you can rent a car and travel through the Garden Route, which will lead you to Knysna, Oudtshoorn, and eventually Cape Town. From Cape Town, Franschhoek is an easy day trip.

Altitude and Acclimatization:
Altitude is not an issue here as these areas are all relatively low lying. Even the highest altitude you might visit, in Franschhoek, is just above sea level.

Accommodation and Booking:
There are a wide variety of places to stay, ranging from budget accommodation to luxury hotels. Book your accommodations in advance to secure the best locations and prices.

Clothing and Essentials:
Pack beach wear for Port Elizabeth and Cape Town, warm clothing for cool evenings, especially in the higher areas around Franschhoek, a good pair of walking shoes, sunscreen, hats and bathing suit.

Health and Safety:
South Africa can be dangerous in certain areas, so always remain vigilant. Avoid displaying valuable possessions in public and carry a copy of your travel documents on you at all times.

Local Etiquette and Respect:
Respect the diverse cultures of the people you encounter. Tipping is customary across the service and hospitality industry.

Remember to always respect local customs and traditions and to be environmentally responsible when visiting natural landmarks.