Definitely, Sydney and Mudgee are both wonderful places to visit. Here's what you need to know:

Best Time to Visit:
The best time to visit Sydney is September through November and from March to May. These months render pleasant weather and more affordable tourist crowds.
Mudgee is a year-round destination but is particularly beautiful in spring (September-November) when many of the flowers and trees are in bloom.

Route and Accessibility:
You can fly directly to Sydney's international airport from most major international cities. From Sydney to Mudgee, you can choose to drive (about 3.5 hours journey), catch a bus, or fly via a regional airline.

Altitude and Acclimatization:
Sydney is near sea level and Mudgee is about 454 meters above sea level so you don't need to worry so much about altitude sickness.

Accommodation and Booking:
There are many options for accommodations in both Sydney and Mudgee. It is recommended to book in advance to secure your stay, especially during the peak tourist season.

Clothing and Essentials:
Sydney's climate is temperate which calls for light clothing in summers and warm in winters. For Mudgee, during winter, it's quite cold so pack accordingly.
Regardless of when you visit, be sure to bring sunscreen, a hat, and sunglasses for protection against the strong Australian sun.

Health and Safety:
Make sure to stay hydrated, use sunscreen liberally and try to stay indoors or in the shade during the hottest parts of the day.
Observe safety rules at beaches and swimming spots in Sydney.

Local Etiquette and Respect:
Australians are pretty laid back but being polite is appreciated. Try to respect local customs and practices, maintain cleanliness in public places, and adhere to any regulations outlined by authorities or site management.