Definitely! Visiting Adana, Mardin, Hatay, and Sanliurfa in Turkey can be an excellent cultural immersion. Here are some tips to simplify your travel:

Best Time to Visit:
The best time to visit these cities in Turkey is during the spring (April to June) and autumn (September to November) periods when the weather is pleasant and less crowded.

Route and Accessibility:
For all these cities, the most convenient way is to fly into Istanbul or Ankara and then take domestic flights. All these cities have airports and are also connected by bus and train routes.

Altitude and Acclimatization:
These cities are not at high altitudes, so there isn't a significant need for acclimatization. Still, do ensure you take time to adjust with the local climate and time zone.

Accommodation and Booking:
Booking in advance is always helpful. There are numerous options for accommodation - from luxurious to budget-friendly.

Clothing and Essentials:
Pack according to the seasons. Summers can be quite hot, so light clothing and sun protection are advised. Winters can be chilly requiring layering and warm gear. It's always good to pack a comfortable pair of walking shoes as there will be plenty of sightseeing.

Health and Safety:
Carry basic medicinal kits, keep yourself hydrated, and look after your possessions. Follow guidelines for COVID-19 precautions. Turkish cities are generally safe, but as with all travel, stay cautious and informed about local conditions.

Local Etiquette and Respect:
Turkey has a rich cultural tradition, and it abides by respectful behavior in religious places. Dress modestly while visiting mosques. It's customary to take off your shoes before entering, and women may need to cover their heads. Understanding a few basic Turkish phrases could aid your interactions with locals.