Absolutely! Visiting Milan, Florence, Rome and Sicily will surely make your Italian rendezvous a memorable journey. Here are some travel tips to enrich your Italian experience:

Best Time to Visit:
April to June and September to October are the excellent time to visit these places when the weather is pleasant and the tourist crowd is less.

Route and Accessibility:
Starting off at Milan, you can travel south to Florence and Rome by high-speed trains. Sicily, being an island, is accessible by plane from Rome or by ferry from Naples.

Altitude and Acclimatization:
Most of these destinations are at low altitudes, so acclimatization won't be a major concern. However, certain areas in Sicily have higher altitudes so if you're planning to trek, take necessary precautions.

Accommodation and Booking:
All these Italian cities have a wide range of accommodations to suit different budgets. Look for centrally located accommodations to access the major attractions easily. Early booking is recommended during peak tourist seasons.

Clothing and Essentials:
Pack lightweight, breathable clothes for the warm summer months and layering options for colder times. Comfortable walking shoes are recommended as these cities are best explored on foot. A sun hat, sunglasses and sunscreen are also must-haves.

Health and Safety:
Follow standard safety precautions, such as keeping an eye on your belongings in busy tourist spots. Italian food is largely safe and enjoyable, but if you have specific food restrictions, inform at restaurants beforehand.

Local Etiquette and Respect:
Italians appreciate politeness, so learning a few Italian phrases like 'please' and 'thank you' can go a long way. When visiting churches, ensure to dress modestly. Additionally, it is customary to say "Buongiorno" (Good day) or "Buonasera" (Good evening) when entering shops or restaurants.