Sure, I'd be happy to provide some tips for travelling to Winnipeg, Regina, Saskatoon and Edmonton:

Best Time to Visit:
The best time to visit these areas are during the summer months, from June to August as the weather is warm and pleasant. However, if you enjoy winter activities you may consider visiting between December and February.

Route and Accessibility:
The Trans-Canada Highway links all these cities. Start your journey in Winnipeg, then drive to Saskatoon, continue to Edmonton and finally, finish at Regina.

Altitude and Acclimatization:
As these cities are not at a high elevation, altitude acclimatization is not a concern here.

Accommodation and Booking:
Book your accommodations in advance, especially if you're visiting in the summer season. All cities provide a wide range of accommodation options from luxury to budget.

Clothing and Essentials:
Light clothing is fine for summers, but make sure to pack a light jacket or sweater for the evenings. If visiting in winter, pack warm clothes and appropriate footwear. Always carry a travel adapter, personal identification, and travel insurance documents.

Health and Safety:
Stay hydrated, especially in summer. Carry personal medical necessities. The local tap water is safe to drink.

Local Etiquette and Respect:
Canadian citizens are usually polite and courteous. Disrespect to anyone because of their ethnicity or religious belief is not tolerated. Always ask before taking pictures of locals as it's considered polite.

Attractions:
Winnipeg- Visit the Manitoba Museum and Assiniboine Park.
Regina- Check out the Royal Saskatchewan Museum and the Saskatchewan Science Centre.
Saskatoon- Visit the Remai Modern museum and the Saskatoon Forestry Farm Park & Zoo.
Edmonton- Visit the Royal Alberta Museum, Fort Edmonton Park and the West Edmonton Mall, the biggest shopping centre in North America.