Absolutely! Your trip across Andhra Pradesh and Telangana, covering the cities of Hyderabad, Visakhapatnam, Vijayawada, and Tirupati promises to be a culturally rich and diverse experience. Here are some travel tips for you:

Best Time to Visit:
Hyderabad and Vijayawada can be visited any time of the year, however, November to February is ideal, when temperatures are cooler. The pleasant time to visit Visakhapatnam and Tirupati is also during the winter months; October to March.

Route and Accessibility:
Start your journey from Hyderabad, then move towards Vijayawada. From there, go to Visakhapatnam, and finally end your trip at Tirupati. This is the most efficient route. Travel between these cities is well facilitated by roadways, railways, and airways.

Altitude and Acclimatization:
These cities are mostly at sea level and relocating between these places should not require specific acclimatization.

Accommodation and Booking:
These cities offer a wide range of accommodations from luxury hotels to budget stays. Make sure to book your accommodation in advance, especially for Tirupati where lodging can get booked up due to the high number of pilgrims.

Clothing and Essentials:
Pack a mix of light clothes for the day and slightly warmer ones for nights. Don't forget your sunglasses, sunscreen, and hats. Carrying an umbrella or raincoat would be a good idea considering unpredictable Indian rains.

Health and Safety:
Keep yourself hydrated. Stay safe while traveling and exploring the cities, carry a basic first aid kit with you.

Local Etiquette and Respect:
South India has a rich cultural heritage, and it's frequently reflected in its temples and local traditions. Dress modestly while visiting temples. Respect local customs, try engaging with the local population, and enjoy regional culinary delights.