Absolutely! Visiting Tokyo, Sendai, Yamagata and Akita will definitely give you a culturally rich and enjoyable traveling experience. Here are some travel tips for you:

Best Time to Visit:
For Tokyo, spring (March to May) and autumn (September to November) are the best times to visit due to mild weather and beautiful cherry blossoms & autumn leaves.

In Sendai, Yamagata, and Akita in Tohoku region, summer (June to August) is also a great time to visit due to pleasant temperatures and the opportunity to experience local festivals. But be ready for humid conditions.

Route and Accessibility:
All these cities are easily accessible with Japan's extensive rail network. Using a Japan Rail Pass can be economical if you're visiting multiple cities.

Altitude and Acclimatization:
These cities are at sea level, so altitude and acclimatization are not issues.

Accommodation and Booking:
Accommodation options in these cities range from budget hostels to luxury hotels. Booking in advance is recommended, especially during peak tourism season and during local festivals.

Clothing and Essentials:
For spring or autumn travel, light daily wear with a layering option is advisable. In summer, lightweight and breathable clothing is essential, while in winter, you will need layers and thermal wear. Comfortable shoes for walking around the city are a must. Also, an umbrella might come in handy as it can rain unexpectedly.

Health and Safety:
Make sure to have travel insurance. Keeping basic medicines and any personal medication is advised.

Local Etiquette and Respect:
The Japanese are very polite and courteous, so be aware of local customs. For example, remember to remove your shoes before entering a traditional Japanese home or certain traditional restaurants.