Absolutely, travelling to Valencia, Maracay, and San Felipe in Venezuela can be an amazing experience. Here are some travel tips for your journey.

Best Time to Visit:
The optimal time to visit these cities would be during the dry season, from December to April. The climate is pleasant and sunny, perfect for outdoor activities.

Route and Accessibility:
From Caracas, the capital of Venezuela, it's around a 2-3 hours drive to Valencia. Regular buses run from Caracas to Valencia, Maracay and San Felipe. Domestic flights are also available to these cities from Caracas.

Altitude and Acclimatization:
The altitudes of these cities are relatively low, so there shouldn't be significant issues with acclimatization. However, since each person's response to altitude can vary, it's still crucial to stay well-hydrated and listen to your body's signs.

Accommodation and Booking:
Valencia, Maracay, and San Felipe offer various accommodation options ranging from luxurious hotels to affordable guesthouses. It's advisable to book your accommodations in advance, especially during peak travel seasons.

Clothing and Essentials:
Lightweight, breathable clothes are perfect for the day time. As evenings might get a little chilly, carrying a light sweater can be useful. Don't forget your sunscreen, hat, and sunglasses.

Health and Safety:
Make sure to get any necessary vaccinations before travelling to Venezuela. Keep a good stock of bottled water, and avoid raw or undercooked food. Pay attention to your belongings and avoid deserted areas, especially at night.

Local Etiquette and Respect:
Venezuelans are very warm and friendly. It's customary to greet with a kiss on the cheek. They appreciate it if you respect their local customs and traditions. Casual dressing is acceptable, but moderate clothing is recommended for religious places. Please be aware that snapping photos might not be welcomed everywhere; always ask for permission when in doubt.