Absolutely! Here's some travel advice for visiting Manaus, Santarém, and Belém:

Best Time to Visit:
Generally, the best time to explore these cities is from June to December, when the area is less affected by rain and high water levels.

Route and Accessibility:
All three cities have airports that are serviced by domestic and international airlines. For intercity travel, there are planes, boats, and buses available.

Altitude and Acclimatization:
These cities are at sea level, so there are no issues relating to altitude sickness or acclimatization. However, the region has a tropical climate that can be quite humid and hot, so it is beneficial to allow yourself some time to get used to the weather.

Accommodation and Booking:
Hotels and hostels are plentiful in all three cities, with a range of options to suit different budgets. During peak seasons, it is beneficial to book your accommodation in advance.

Clothing and Essentials:
Pack lightweight, breathable clothing to stay comfortable in the tropical heat. Don't forget to bring sunscreen, hats, and bug repellent to protect yourself from the sun and insects. Also important are a water bottle and comfortable walking shoes.

Health and Safety:
Stay updated on vaccines recommended for Brazil. Protect yourself against mosquito-borne diseases such as dengue fever, yellow fever & zika virus by wearing bug repellent and covering exposed skin. Stay hydrated to beat the heat.

Local Etiquette and Respect:
These cities are part of Brazil's Amazon region and are rich in indigenous cultures. Be respectful of local traditions and cultural sites. Also, learning a few basic phrases in Portuguese, the local language, can be highly beneficial and well-received.