Of course! Visiting San José, La Fortuna, and Manuel Antonio in Costa Rica is an adventurous trip. Following are some tips for your travel:

Best Time to Visit:
The best time to visit these places is during the dry season from mid-December to April. However, if you want to avoid the crowd, May and June are great months when the rainy season just begins but the rainfall is not too heavy.

Route and Accessibility:
San José is accessible via direct flights from many major international cities. From San José, you can take a public bus or a rental car to La Fortuna which is a 3-4 hours journey. Similarly, Manuel Antonio is about a 3-4 hours drive from San José.

Altitude and Acclimatization:
San José is at an elevation of about 1,100 meters, La Fortuna is around 200 meters, and Manuel Antonio is at sea level. As these are not extreme altitudes, acclimatization is typically not an issue.

Accommodation and Booking:
All these locations have a good mix of accommodations ranging from budget hostels to luxury resorts. It is recommended to book your accommodations in advance, especially during the peak travel season.

Clothing and Essentials:
Pack for warm, tropical weather but also prepare for rain particularly if you're visiting during the rainy season. It's a good idea to bring a swimsuit, sunscreen, insect repellent, sturdy shoes for hiking, and a waterproof jacket.

Health and Safety:
Use bottled water for drinking. If you're planning to do any adventure activities like ziplining or white-water rafting, ensure that you're using a reputable operator who prioritizes safety.

Local Etiquette and Respect:
Costa Ricans, known as Ticos, are generally welcoming and friendly. A basic understanding of Spanish is beneficial. Remember to respect local customs and traditions. In national parks, follow the guidelines to help preserve the natural environment.