Absolutely! Travelling to Bayreuth, Weimar, Leipzig, Dresden offers an amazing experience of rich cultural heritage and beautiful architecture. Here are some travel tips to ensure a smooth journey.

Best Time to Visit:
The best time to visit these German cities is during the spring (April to June) and fall (September to October), when the weather is mild and pleasant.

Route and Accessibility:
You can travel to these cities comfortably by train. Deutsche Bahn, Germany's national railway company, connects all these cities perfectly. You can start with Bayreuth, then move to Weimar, Leipzig, and finish your trip in Dresden.

Altitude and Acclimatization:
These cities are not at very high altitudes, so acclimatization should not be an issue.

Accommodation and Booking:
All these cities have an ample of accommodations ranging from luxury hotels to budget hostels. It is recommended to book your accommodation in advance, especially during festival seasons in Bayreuth and Leipzig.

Clothing and Essentials:
Germany has a temperate seasonal climate, so pack accordingly. Don't forget comfortable walking shoes as these cities have a lot to explore by foot. Carrying an umbrella or a raincoat would be a good idea as rain can be unpredictable.

Health and Safety:
Germany is generally a safe country to travel. However, carry your necessary medications and maintain hygiene practices to avoid any health issues.

Local Etiquette and Respect:
Germans are known for their punctuality and directness. Respect their norms and tradition. Also, note that in Germany you should acknowledge people with their last name unless suggested otherwise.

Remember to validate your tickets while using public transport as fines can be hefty. The locals appreciate if you can speak a few phrases in German, even if it is just 'Danke' (Thank you). Enjoy your trip!