Sure, sounds like a fantastic trip down the California coast! Here's what I suggest:

Best Time to Visit: The best time to take this trip is from March to May or from September to November. The weather is pleasant during these months and you'll beat most of the summer crowds.

Route and Accessibility: You can start your trip in San Francisco and follow Highway 1 down the coast to Los Angeles. Monterey, Big Sur, and Santa Barbara will all be along this route.

Altitude and Acclimatization: The elevation in these cities is not high, so acclimatization is not typically a concern.

Accommodation and Booking: San Francisco, Monterey, Santa Barbara, and Los Angeles all have plenty of accommodation options. It's best to book hotels and flights in advance particularly if you're traveling during peak season.

Clothing and Essentials: Pack layers, as temperatures can vary. Also bring comfortable walking shoes, as there is a lot of sightseeing in these cities. Don't forget your bathing suit for the beach and sunscreen.

Health and Safety: Be aware of your surroundings and keep your valuables secure, especially in crowded tourist areas.

Local Etiquette and Respect: Californians are generally laid back. However, it is good to know that tipping is expected in restaurants, and cultural landmarks often hold deep historic or spiritual meaning. Respect these sites by following any posted rules or requests.

Also, keep in mind to have a valid driver’s license and insurance if you plan to rent a car for the journey and equip yourself with a good GPS or travel map of the state.

Hope these tips help you plan a fantastic trip!