Absolutely! These towns along England's South coast each have a different charm. Here are some travel tips for your journey:

Best Time to Visit:
The best time to visit Exeter, Sidmouth, Lyme Regis, and Weymouth is typically from late spring to early fall (May to September). The weather is most pleasant during these months, and you can enjoy outdoor activities.

Route and Accessibility:
All these towns are well connected by road and rail network. You may start your journey from Exeter, proceed to Sidmouth then Lyme Regis followed by Weymouth.

Altitude and Acclimatization:
These towns are at sea level so there won't be issues regarding altitude and acclimatization. However, as you'll be near the sea, it can get quite windy at times.

Accommodation and Booking:
There are a wide variety of accommodation options available in these popular tourist spots ranging from luxury hotels to charming bed and breakfasts. Remember to book in advance, especially during peak summer months.

Clothing and Essentials:
Carry clothes suitable for the season during which you are traveling. It can get colder near the sea, so it's wise to carry a jacket. Also, carry sunscreen, hats, and sunglasses to protect yourself from the sun. Comfortable walking shoes are essential as these towns are best explored on foot.

Health and Safety:
Many of these towns are quite safe, but as with any travel, do not leave your belongings unattended. Check for any local health advisories before your visit.

Local Etiquette and Respect:
These areas are known for their history, marinas, and old-world charm. Be respectful of these historical places. If you're visiting any of the local churches, dress modestly.

Finally, make sure to try the local seafood and explore the local nature reserves for an authentic experience. Happy travels!