Hello! That sounds like an exciting adventure to the beautiful Czech towns of Znojmo, Mikulov, and Velké Pavlovice. Here are some travel tips to consider:

Best Time to Visit:
The best time to visit these towns is in the spring (April to June) and autumn (September to October), when the weather is mild and pleasant. The towns are also beautiful during the grape harvest seasons in September, which is quite a popular time for tourists.

Route and Accessibility:
You can reach Znojmo from Prague by taking a train or a bus, which usually takes around 3 hours. From Znojmo, you can reach Mikulov by bus in approximately two hours. From Mikulov, Velké Pavlovice is a short bus ride or drive away. Renting a car could make your transfers between these towns more flexible.

Accommodation and Booking:
There are a variety of accommodations available in these towns ranging from boutique hotels to beautiful homestays. It's recommended to book your accommodations in advance, especially if you plan to visit during peak tourist season or during a local festival.

Clothing and Essentials:
Pack clothing suitable for mild weather and a good pair of walking shoes as these towns are best explored on foot. Don't forget your camera, a water bottle, sunscreen, and any necessary personal medication.

Health and Safety:
Czech Republic is generally safe for tourists. However, always pay attention to your personal belongings and ensure your travel insurance is up to date. It's also a good idea to check any travel advisories before your trip.

Local Etiquette and Respect:
Czech people appreciate good manners. Simple gestures such as saying 'thank you' and 'please' are appreciated. If you're visiting any churches or religious sites, dress respectfully and behave quietly to respect the local customs.