Absolutely! Travelling across Africa can be a fascinating experience. Let me provide some travel tips for Cairo, Nairobi, Johannesburg, and Cape Town.

Cairo, Egypt:
Best Time to Visit:
The best time to visit Cairo is during the cooler months from November to March.
Route and Accessibility:
Cairo has an international airport which is accessible from most parts of the world. The city has well organized public transportation, taxis and Ubers are quite affordable.
Accommodation and Booking:
There's a wide range of accommodation options in Cairo from budget hostels to luxury hotels. Booking in advance is advisable.
Clothing and Essentials:
Given Cairo's hot dry desert climate, light clothing is recommended for your trip. However, to respect local customs you should wear conservative attire in public places.
Health and Safety:
Stick to bottled water and avoid salads or fruits that can't be peeled to prevent Traveller’s Diarrhea.
Local Etiquette and Respect:
Egyptians are generally helpful and friendly. However, try to respect their customs and traditions.

Nairobi, Kenya:
Best Time to Visit:
The dry season (late June to October) is the best time for a wildlife safari in Nairobi.
Route and Accessibility:
Nairobi is well connected by flights around the world. You can use taxis, matatu (mini buses) or boda-boda (motorcycle taxis) for local commute.
Accommodation and Booking:
A variety of accommodations from luxury to budget options are available. It's recommended to book in advance.

Johannesburg and Cape Town, South Africa:
Best Time to Visit:
The best time to visit both cities is during their summer months (November to March) for beach visits. For wildlife in Johannesburg, May to September (their winter) is a good time.
Route and Accessibility:
Both cities have international airports, and local transport includes buses, taxis, and car rentals.
Accommodation and Booking:
From budget to luxury, both cities offer a wide range of accommodations. Online booking in advance is recommended.
Clothing and Essentials:
For the beach climate of Cape Town, light clothing and sunblock are essential. But for Johannesburg and its game reserves, pack light clothing for hot days and warm clothing for cool mornings and nights.
Health and Safety:
Stick to tourist areas, especially at night, to avoid crime in Johannesburg. General safety precautions would be the same as any other city.
Local Etiquette and Respect:
South Africans are friendly and warm. Respect local customs and traditions. In tourist areas, it is customary to tip at restaurants.

Always ensure to have travel insurance, it is better to be safe than sorry. These tips also depend on the current situation of the country's state and pandemic regulations. It's advisable to check the current regulations before planning your travel.