Hello! It's great to hear that you are planning a trip to Cairo, Nairobi, Johannesburg, and Cape Town. Here are some travel tips to make your journey memorable.

Best Time to Visit:
The best time to visit Cairo in Egypt is from October to April when the weather is milder. For Nairobi, the ideal months would be July through October and January to March. Johannesburg and Cape Town in South Africa are excellent to visit between October to April, which is the southern hemisphere’s summer.

Route and Accessibility:
The most accessible route would be starting from Cairo, taking a flight to Nairobi, then another flight to Johannesburg, and finally a drive down to Cape Town. All cities have international airports and are well connected by road networks.

Accommodation and Booking:
You can find a range of accommodations in all these cities. From luxury hotels to budget-friendly options, there's plenty to choose from. It's recommended to book well in advance, especially during peak tourist seasons.

Clothing and Essentials:
Pack layers and a mix of clothing suitable for both hot and cooler climates given the destinations. Sunscreen, hats, comfortable walking shoes, and insect repellent would be essential. Also, remember to pack a universal travel adapter for your electronics.

Health and Safety:
It's advisable to get vaccinations for Hepatitis A, Typhoid, and Yellow Fever before your trip. Stay aware of your belongings and avoid isolated areas at night. Drinking only bottled water and eating well-cooked food is recommended.

Local Etiquette and Respect:
While in Cairo, dress modestly especially when visiting religious sites. Be polite and avoid sensitive topics. In South Africa, respect local traditions and avoid politically sensitive topics. In Nairobi, shaking hands is a common form of greeting.