Definitely! Traveling to San Francisco, Chicago, and New York City sounds exciting. Here are some travel tips for a smooth journey:

Best Time to Visit:
The best time to visit these cities can vary. For San Francisco, September to November is the ideal time. However, for Chicago, the best time is from September to October, whereas for NYC, the best time is April to June, and September to early November avoiding extreme summer and winter conditions.

Route and Accessibility:
All three cities have world-class international airports and are well connected by road and rail networks. Transportation with cities is also efficient with buses, taxis, or subway metro systems.

Altitude and Acclimatization:
Altitude is not an issue in these cities, except for slight temperature changes. Do check the weather forecast to align your travel itinerary accordingly.

Accommodation and Booking:
All three cities offer a wide range of accommodations. It's advisable to book in advance, especially if traveling during peak tourist season or during major events. Airbnb can be a good budget-friendly option.

Clothing and Essentials:
Pack according to the season. For chilly weather, layering is key. Comfortable walking shoes are a must, as all three cities are best explored on foot. Also, don’t forget an umbrella/raincoat, especially for San Francisco.

Health and Safety:
While all three cities are generally safe, it's best to avoid poorly lit or deserted areas at night. Keep emergency contact numbers. The food and water in these cities is safe for consumption. Remember, American portion sizes can be quite large, be cautious if you're watching your caloric intake.

Local Etiquette and Respect:
Americans generally appreciate personal space. Tipping is customary in U.S (15-20% of the bill at restaurants). Do remember to follow the instructions of local authorities, respect the local culture, and adhere to public rules and regulations at all times. San Francisco and New York City are plastic-bag free cities, so carry a reusable bag.