Absolutely! Visiting Venice, Florence and Rome can be an amazing cultural and historical journey. Here are some tips to enhance your travel experience:

Best Time to Visit:
The ideal time to visit cities like Venice, Florence and Rome is during spring (April to June) or Fall (September and October) when the weather is pleasant.

Route and Accessibility:
The best way to travel between these cities is by train. Italian trains are efficient and offer stunning views of the Italian countryside. Start from Venice, then move to Florence and lastly to Rome.

Altitude and Acclimatization:
These cities are not located at high altitudes, hence acclimatization is not much of an issue. However, it's important to be aware of the weather and stay hydrated, especially during the summer.

Accommodation and Booking:
Booking hotels in advance is highly recommended as Italy can be quite crowded during peak tourist seasons. Consider staying in central areas for easy accessibility to major attractions.

Clothing and Essentials:
Pack according to the season. Summers can be quite hot so bring light clothes and a strong sunscreen. During winters, it can get quite cold so heavier clothing is recommended. Comfortable walking shoes are a must as these cities are best explored on foot.

Health and Safety:
Remember to carry any necessary medications, standard first-aid, and keep yourself hydrated. Italian cuisine can be rich and varied, so if you have any allergies, make sure to ask about ingredients in dishes.

Local Etiquette and Respect:
When visiting religious sites, dress modestly and remember to be quiet and respectful. Many museums and attractions in Italy require tickets, some of which you can buy in advance to avoid long queues. Additionally, tipping in restaurants is usually around 10% of the bill.