Absolutely! Spain is a beautiful country with a rich cultural heritage. Here are some travel tips for your visit to Madrid, Valencia, Barcelona, Zaragoza, and Seville:

Best Time to Visit:
The best time to visit Spain is during the spring (April to June) or fall (September and October). The temperatures are generally comfortable and the tourist crowds are smaller than in summer.

Route and Accessibility:
Spain has one of the best public transportation systems in the world. Trains travel between most major cities and are a comfortable and efficient way to travel.

Altitude and Acclimatization:
These cities are at low altitudes, so you should not face altitude sickness. However, if you're not used to walking long distances, take it easy. Spain’s cities are known for their walkability.

Accommodation and Booking:
Spain has a wide range of accommodation, from luxury hotels to budget hostels. It's advisable to book your accommodation in advance, especially during peak tourist seasons.

Clothing and Essentials:
If you're traveling in spring or fall, pack for slightly cooler weather. Rain can occur periodically, so a waterproof jacket would be handy. Comfortable shoes for walking are essential. Don't forget your sunscreen, Spain is sunny in most seasons.

Health and Safety:
Spain is generally a safe country, but it's always wise to be vigilant about your belongings in crowded touristic areas. Also, always keep your important documents and cash in a safe place.

Local Etiquette and Respect:
Spanish people respect their siesta hours which is usually mid-afternoon. Consequently, many businesses are closed at this time. Also, it's typical for Spanish people to dine late in the evening, usually after 9pm.

Spanish is the native language, so it would be helpful to learn some basic phrases. Spain has a rich historical heritage, so do respect all historical monuments and heritage sites.