Absolutely! La Spezia and Vernazza are both beautiful towns in the Liguria region of Italy. Here's some advice to make your trip go smoothly:

Best Time to Visit:
The best times to visit La Spezia and Vernazza (one of the five villages in Cinque Terre) are late spring and early fall, particularly May, September, and October when the weather is warm and crowds are smaller.

Route and Accessibility:
La Spezia is directly accessible by train from major Italian cities like Florence, Milan, and Rome. From La Spezia, you can take a local train to Vernazza, which takes about 15 minutes.

Altitude and Acclimatization:
Both towns are sea-level so altitude isn’t an issue. However, if you plan to go hiking in the hills around Vernazza, pace yourself according to your abilities.

Accommodation and Booking:
Accommodation options for both La Spezia and Vernazza range from luxury hotels, to seaside villas, to budget-friendly hostels. It's recommended to book your lodging in advance, especially during the high-tourist summer months.

Clothing and Essentials:
Pack lightweight, comfortable clothes and shoes for exploring. However, do remember to bring a few heavier layers as it may get cool in the evenings. If you're planning to hike, make sure you have good walking shoes. Don't forget sun protection (hat, shades, and sunscreen).

Health and Safety:
Watch out for pickpockets in crowded tourist areas. Also, remember to keep hydrated and apply sunscreen frequently.

Local Etiquette and Respect:
Italians appreciate courtesy and politeness, so common phrases like "please", "thank you", and "excuse me" in Italian could be beneficial. While visiting any churches, remember to dress modestly -- cover your shoulders and avoid wearing shorts or skirts above the knee.