Absolutely! Your trip to Puerto Vallarta, Guadalajara, and Riviera Maya will be filled with rich culture, beautiful beaches, and wonderful heritage sites. Here are some tailored travel tips for your journey:

Best Time to Visit:
The period between April to June is ideal when the weather is pleasant and prices are lower than the peak season. The Rainy season starts in Late June and goes till October.

Route and Accessibility:
Puerto Vallarta and Riviera Maya have international airports and are easily accessible. Guadalajara is connected via Mexico City Airport. Local transportation includes buses, taxis, or rental cars.

Altitude and Acclimatization:
While these places do not have high altitudes to worry about acclimatization, it's good to take some time adjusting to the local climate especially in Riviera Maya which is tropical and humid.

Accommodation and Booking:
There is a wide range of accommodation options ranging from budget to luxury. It's advisable to book in advance especially in peak season. In Riviera Maya, all-inclusive resorts are popular.

Clothing and Essentials:
Light, breathable clothing is recommended due to the warmer climate. Don't forget swimwear, sunblock, hat, comfortable shoes, and a good insect repellent.

Health and Safety:
Make sure to drink bottled water and take precautions with street food. Keep an eye on your personal belongings in busy areas and use safe transportation options.

Local Etiquette and Respect:
Respect local customs and traditions. Try to learn basic Spanish phrases as it will help in navigating and interacting with locals. Be aware of environmental duties, especially in sensitive ecosystems like the Mayan ruins.

Have a splendid journey and enjoy the beauty and culture these places offer!