Sure! Visiting Cairo and Sharm El-Sheikh offers a mix of history and natural beauty. Here are some travel tips for you:

Best Time to Visit:
Cairo can be visited throughout the year, but the months between October and April are most pleasant due to cooler temperatures. Sharm El-Sheikh is beautiful throughout the year, but if you're interested in scuba diving, April to October is considered the best time.

Route and Accessibility:
You can reach Cairo via its international airport. From Cairo, Sharm El-Sheikh is easily accessible by road, air, or ferry across the Red Sea.

Altitude and Acclimatization:
Both Cairo and Sharm El-Sheikh are near sea-level, so altitude sickness is not a concern. However, if you plan to climb Mount Sinai near Sharm El-Sheikh, take slow steps to acclimatize to the altitude.

Accommodation and Booking:
Both cities offer a wide range of accommodations from budget options to luxury resorts. It's advisable to book in advance, especially during the peak tourist season.

Clothing and Essentials:
Egypt can be hot and sunny, so lightweight clothing, sunblock, hats, and sunglasses are recommended. But remember, Egypt is predominantly a Muslim country, so respect the local culture by dressing modestly, especially when visiting religious sites.

Health and Safety:
Ensure you're updated with your routine vaccinations. Tap water in Egypt is not safe to drink, so drink only bottled water. Additionally, carry a travel insurance for any unforeseen circumstances.

Local Etiquette and Respect:
Respect local customs and traditions. Arabic is the main language in Egypt, but English is widely spoken in tourist areas. Tipping (baksheesh) is a common practice for services provided.

Lastly, make sure you taste the local cuisine and enjoy an authentic Egyptian meal amongst locals!