Absolutely! Travelling to Rosario, Córdoba, and Mendoza in Argentina could be a fascinating experience. Here are a few tips:

Best Time to Visit:
The ideal time to visit Rosario and Córdoba is between March to May and September-November when fall and spring bring mild temperatures. For Mendoza, the best season would be fall, from March to May, for winery tours and a gorgeous autumnal landscape.

Route and Accessibility:
Fly in to Buenos Aires' international airport, then take domestic flights or long-distance buses to Rosario, Córdoba, and Mendoza. Each city is well-connected via road and rail to Buenos Aires and each other.

Altitude and Acclimatization:
Córdoba and Rosario are at low altitudes so acclimatization should not be an issue. Mendoza is also relatively low but closer to the Andean mountains. A day or two for acclimatization before exploring higher altitude areas should suffice.

Accommodation and Booking:
Plenty of accommodations ranging from hostels, B&Bs, higher-end hotels are available in each city. Booking in advance, particularly during festival season in Mendoza, is advised.

Clothing and Essentials:
Wear comfortable casual clothes suitable for warm days and cooler nights. A hat, sunglasses, sunblock, and bug spray may also be useful. Also, pack an outlet adapter for Argentina's Type I socket.

Health and Safety:
Stay hydrated, especially when consuming alcohol in Mendoza's wine regions. Carry a basic first aid kit and any prescribed medications. Beware of pickpockets in crowded tourist spots.

Local Etiquette and Respect:
Argentinians are warm and friendly people. Learn a few Spanish greetings and phrases - it's appreciated. Dress appropriately when visiting religious and culturally significant sites. Respect the customs and traditions of the local communities.