Of course! Visiting these Spanish cities will surely be an intriguing experience. Here are some travel tips for your journey:

Best Time to Visit:
The finest times to visit Madrid, Valencia, Barcelona, and Zaragoza are in the spring (March to May) and fall (September to November) when the weather is pleasant. These cities can get really hot in the summer and pretty cold in the winter.

Route and Accessibility:
Spain has a well-connected transportation system. From Madrid, it's a 2-hour high-speed train to Valencia, further you can take a 3-hour train to Barcelona and then another 2-hour train to Zaragoza. It's also easy to fly, and renting a car is another option.

Accommodation and Booking:
Make use of booking platforms like Booking.com, Airbnb, and others to find accommodation that suits your preferences and budget. Book in advance, especially if you're traveling during peak tourist seasons.

Clothing and Essentials:
Pack light with comfortable clothing relevant to the season of your visit. Don't forget your swimwear if you're planning on hitting the beaches in Valencia. Carry a good-quality sunscreen too.

Health and Safety:
Spain is relatively safe for tourists but do pay attention to your belongings to avoid pickpockets in crowded areas. Don't forget to carry a basic first-aid kit and any prescribed medication, and also invest in travel insurance.

Local Etiquette and Respect:
Spanish people appreciate courtesy and good manners. Learn a few basic phrases in Spanish; it'll help you connect with locals. Be respectful of local customs, especially when visiting religious sites.