Absolutely, it's exciting that you are planning a trip to British Columbia, Canada.

Best Time to Visit:
The best time to visit these cities is from May to October. During these months, you get to enjoy outdoor activities and explore the region's wine country.

Route and Accessibility:
All these cities are well connected by roads and can be accessed through a scenic drive along the Pacific coast, via Highway 1 or 3. There is also air connectivity to Vancouver and Kelowna, after which you can rent cars to travel locally.

Altitude and Acclimatization:
These cities are mostly at sea level or lower altitude, hence acclimatization is not a big concern.

Accommodation and Booking:
Bookings can be made online in advance for a comfortable stay in hotels or motels. There are also unique accommodation options like wine estates and lakefront resorts available.

Clothing and Essentials:
Pack according to the season. If it’s summer, shorts, light shirts and dresses are fine with a light sweater for the evenings. In the winter, warm clothing is needed as temperatures can go below freezing point.

If you plan on visiting local vineyards, it’s best to carry a sunhat, sunscreen and comfortable shoes.

Health and Safety:
Basic healthcare facilities are readily available. Drink plenty of water especially if you plan on wine tasting. It's generally a safe region, but always follow local advisories.

Local Etiquette and Respect:
Canadians are known for their politeness. Respect local customs and regulations. In wine estates, it’s polite to buy a bottle after a free tasting.

Remember, don’t drink and drive. Most vineyards and wine tours have arrangements for transport or designated drivers. Enjoy your trip!