Surely! All four cities are splendid destinations with rich history and culture. Here are some travel tips for your journey:

Best Time to Visit:
The ideal time to visit Zürich, Innsbruck, Munich, and Salzburg is during the late spring (April - June) and early fall (September - October) when the weather is mild. Winters can be a good time too, especially if you enjoy winter sports.

Route and Accessibility:
​​You can start in Zürich and take the train to Innsbruck (around 3.5 hours), then onto Munich (1.5 hours), and finally to Salzburg (1.5 hours). The rail network is excellent with reliable and frequent train services.

Altitude and Acclimatization:
Zürich, Munich, and Salzburg are located at relatively low altitudes; Innsbruck is a bit higher but shouldn't need particular acclimatization. However, feel free to take it slow and make sure to stay hydrated.

Accommodation and Booking:
Booking in advance is advised to get the best deals and secure a place that meets your preferences. All the cities offer a range of accommodations from budget hostels to luxury hotels.

Clothing and Essentials:
Pack according to the season in which you're visiting! For spring and autumn, light layers will work. For winter, you'll want to bring warm clothing. Regardless, comfortable walking shoes are a must for exploring these cities.

Health and Safety:
Ensure you have travel insurance in case of sudden health issues. All the cities are relatively safe, but just like any location, it's important to be aware of your surroundings, especially at night.

Local Etiquette and Respect:
Europeans appreciate punctuality. Tipping is standard in restaurants. Learning a few basic phrases in the local languages can be useful and is often appreciated.

Don't forget to respect local laws and customs, and always be mindful of noise levels, especially in quieter neighborhoods or late at night.