Absolutely, Turkey is rich with culture, history, and breathtaking landscapes. Here's some guidance for your tour in Istanbul, Edirne, Bursa, and Ankara:

Best Time to Visit:
For Istanbul, April to June and September to November (when the weather is pleasant, and there are fewer tourists) are the ideal periods to plan your visit. In Ankara, the best time is late April to May and October to November. Bursa and Edirne are ideal from April to mid-June, and September to November.

Route and Accessibility:
To get a complete Turkish experience, you can start your journey with Istanbul's bustling city life, then take a bus or taxi to Edirne, and from there, a car or bus to Bursa. From Bursa, you can take a bus or a domestic flight to Ankara.

Altitude and Acclimatization:
These cities are not at high altitudes so acclimatization is not usually an issue. However, still keep yourself well hydrated and rested.

Accommodation and Booking:
Accommodation ranges from budget to luxury in all these cities. It's advisable to book your accommodations in advance, especially during peak tourist seasons.

Clothing and Essentials:
Light clothing is sufficed for the summer months while warm clothing is needed for winter. Do remember to pack comfortable walking shoes for sightseeing.

Health and Safety:
Be aware of your surroundings, especially in crowded places. Keep your valuables safe. Turkish tap water isn't highly recommended for drinking, so bottled water might be a safer option.

Local Etiquette and Respect:
Turkish people are warm and friendly. When visiting mosques, dress modestly and women are expected to cover their heads. Respect the local traditions and customs. Enjoy the delicious Turkish cuisine!