Hello! It sounds like you're about to embark on an exciting journey to the Shikoku region of Japan, visiting Tokushima, Kochi, Ehime, and Kagawa. Here are some useful travel tips to consider.

Best Time to Visit:
The best time to visit these prefectures is likely in the Spring (March to May) when the cherry blossoms are in full bloom or in Fall (September to November) for the colorful foliage. However, the Awa Dance Festival in Tokushima every August is another fantastic time to visit.

Route and Accessibility:
The best way to access the Shikoku region is by air into Tokushima Awaodori Airport, or by train or bus from larger cities like Osaka and Kobe. Once in the region, local trains, buses and ferries are the primary means of transportation.

Accommodation and Booking:
Accommodations range from modern hotels to traditional ryokan guesthouses. It is advisable to book in advance, especially during popular travel seasons. Many accommodations can be booked via common travel booking websites or through the tourism offices' websites.

Clothing and Essentials:
Pack light layers for the spring and autumn, and heavier clothing for the colder winter months. A raincoat or umbrella could come in handy as Shikoku can have frequent rainfall. Don't forget comfortable footwear, especially if you plan to do a lot of walking or hiking.

Health and Safety:
Japan is generally quite safe, but be mindful of your belongings and of natural disasters such as earthquakes and typhoons. It's recommended to have travel insurance and keep emergency contact numbers handy. If you have dietary restrictions, be sure to communicate them clearly as English isn't widely spoken outside of the major cities.

Local Etiquette and Respect:
Japanese culture appreciates politeness and respect. Familiarize yourself with basic Japanese etiquette, such as bowing when greeting, removing shoes before entering traditional buildings, and following local rules and restrictions closely.