Absolutely! Planning to explore Japan from Tokyo to Aomori is a delightful decision. You're going to acquaint yourself with rich cultural experiences. Here are some tips to enhance your journey:

Best Time to Visit:
You can visit Tokyo and surrounding areas all year round, though April to June and September to November are particularly pleasant due to moderate weather and lovely sceneries offered by Cherry Blossom (in Spring) and Autumn leaves respectively. For Aomori specifically, late July to August is the best time if you wish to attend the famous Aomori Nebuta Festival.

Route and Accessibility:
You can use Japan's efficient and punctual train system. From Tokyo, you can visit Nikko (2 hours via Tobu-Nikko Line), then Sendai (2 hours from Tokyo via Tohoku Shinkansen), and finally Aomori (3 hours from Sendai by Shinkansen).

Altitude and Acclimatization:
Generally, these locations are not at high altitudes, so acclimatization isn't an issue. However, staying hydrated and rested during travel is always beneficial.

Accommodation and Booking:
Booking your accommodations well in advance is advisable, especially during busy seasons. Both traditional ryokans and hotels are available in these areas.

Clothing and Essentials:
Pack according to the season of your visit. Comfortable walking shoes are essential because exploring the cities often involves a good amount of walking. Carrying a raincoat or small umbrella could be necessary as rain can be unexpected.

Health and Safety:
Japan is considered a safe country to travel. Just as always, keep a first aid kit handy, carry sufficient masks and sanitizers considering the pandemic situation, and keep your health insurance details with you.

Local Etiquette and Respect:
Japanese are known for their discipline and manners. Try to follow local etiquette- speak softly, avoid littering, respect queues and removing your shoes before entering a traditional Japanese room or sacred place. It might be beneficial to learn a few basic phrases in Japanese to help you get around.