Hello! That sounds like an exciting trip to Panama. I'd be happy to help you with some travel tips for your visit to Penonomé, Ocú, and Las Tablas.

Best Time to Visit:
The best time to visit these Panamanian cities is during the dry season, from mid-December to mid-April. Please note the Carnival, a popular event in Las Tablas, happens before Lent (usually in February).

Route and Accessibility:
The quickest way is by air, landing at Tocumen International Airport in Panama City. From there, you can take a bus or rent a car to reach Penonomé, which is about a 2-hour drive. Ocú and Las Tablas are further south and take about 4 and 5 hours to reach respectively.

Accommodation and Booking:
You'll find a range of accommodations to choose from in all three cities, from hotels to vacation rentals. It's advisable to book your accommodations ahead of time, especially during peak travel dates. Websites like Booking.com, Expedia, and Airbnb can offer varied options.

Clothing and Essentials:
Pack light, breathable clothing due to Panama's tropical climate. Don't forget your swimsuit, sunscreen, bug spray, a good pair of walking shoes, and a hat or visor for sun protection.

Health and Safety:
Ensure you’re up-to-date with routine vaccines before your trip. Travellers' diarrhea is common, so consider carrying an anti-diarrheal drug. Use bottled water for drinking and brushing teeth. Also, as the sun can be strong, ensure consistent application of a high factor sunscreen.

Local Etiquette and Respect:
Panamanians are generally friendly and polite. It's good to greet people before starting a conversation. Dress modestly when visiting rural areas and churches. Tipping is a common practice.