Absolutely! Exploring Tunis, Kairouan, and Sfax in Tunisia makes for an exhilarating cultural experience. Here are some travel tips for your visit:

Best Time to Visit:
The best times to visit Tunisia for ideal weather are March to May and September to November. It's during this time that temperatures are moderate, and rainfall is minimal.

Route and Accessibility:
Trains and buses connect Tunis, Kairouan, and Sfax, making travel between these cities easy. However, privately renting a car might offer you more flexibility.

Altitude and Acclimatization:
These Tunisian cities are located at relatively low altitudes, meaning acclimatization is not typically necessary. However, it would be best to stay hydrated and take breaks on your sightseeing tours to avoid excessive fatigue.

Accommodation and Booking:
It's highly recommended to book your accommodations in advance. Ranging from luxury hotels to budget-friendly guesthouses, these cities offer various accommodation options.

Clothing and Essentials:
Tunisians dress modestly, especially in religious and traditional sites. Lightweight clothes in summer and layers for the cooler months are advisable. Don't forget sun protection essentials, like hats, sunglasses, and sunscreen. Comfortable walking shoes are also important.

Health and Safety:
Ensure travel insurance that covers general health issues is in place. Stick to bottled water for drinking and stay updated with any travel advisories for the region. The cities are generally safe, but like anywhere, it's wise to be cautious of your belongings.

Local Etiquette and Respect:
As Tunisia is an Islamic country, respecting local traditions and customs is vital. It's essential to dress modestly, particularly while visiting mosques and old town (medina). Always ask for permission before taking photographs of locals.

Remember, English isn't spoken widely outside the tourist spots, so knowing some basic French or Arabic phrases will be helpful.

Enjoy your trip, and take in the rich culture and history of these remarkable Tunisian cities!