Definitely, travelling to Guatire, San Joaquin, and San Carlos in Venezuela can be a unique experience. Here are some travel tips to ensure your journey is enjoyable:

Best Time to Visit:
The peak tourist season is during the dry season from December to March, but the weather is generally warm and tropical all year round.

Route and Accessibility:
You can reach these places via public transportation, specifically by buses. Check with local tour operators for the best route.

Altitude and Acclimatization:
These cities are at relatively low altitude so acclimatization shouldn’t be a concern.

Accommodation and Booking:
It's always a good idea to book your accommodations in advance to avoid last-minute hassles. There are various types of accommodation to suit different budgets from luxury hotels to budget guesthouses.

Clothing and Essentials:
Bring light clothes for the daytime and an extra layer for chilly evenings. A sturdy pair of shoes for walking tours and sightseeing is recommended. Don't forget your sunblock, as the Venezuelan sun can be pretty intense.

Health and Safety:
Though these areas are quite safe, it's advisable to take normal precautions. Be cautious about your belongings, avoid isolated areas after dark and only drink bottled or filtered water.

Local Etiquette and Respect:
Venezuelans are warm, friendly and family-oriented. Respect the local customs and traditions. Try to learn a few basic phrases in Spanish, as English is not widely spoken.

Remember, these tips are general so it’s worth doing more detailed research about each place closer to your travel dates for updates on the weather and any local events or festivals happening during your visit.