Absolutely! A trip through the old Silk Road is a journey through history and culture. Here's some advice:
Best Time to Visit:
- Xi'an:
Early May to Late September
- Kashgar:
May to October
- Samarkand:
Mid-March to May or September to early November
- Istanbul:
April, May, September, and October

Route and Accessibility:
- The journey usually starts from Xi'an, then to Kashgar before heading to Samarkand, and Istanbul. Train and air travel options are available between these cities.

Altitude and Acclimatization:
- While Xi'an, Samarkand, and Istanbul are at low altitudes, Kashgar lies at about 1,289 meters above sea level. Mild altitude sickness might be experienced, but usually not severe.

Accommodation and Booking:
- It's better to book accommodation in advance. Given the cities are popular tourist spots, lots of hotels are available.

Clothing and Essentials:
- Dressing styles can significantly vary. In the Muslim majority cities like Kashgar, Samarkand, and Istanbul, modest clothing is advisable.
- Don't forget to bring a reliable pair of walking shoes, sunglasses, hat, sunscreen, and a lightweight raincoat.
- Electrical converter or adapter as these countries have different plug types and voltage.

Health and Safety:
- Stick to bottled water and freshly cooked food. Avoid undercooked food or products from street vendors.
- Personal safety is generally high but as with any travel, keep an eye on your personal belongings.

Local Etiquette and Respect:
- Respect the local customs and etiquette wherever you are and try to learn a few phrases in local languages.
- When visiting mosques in Istanbul, women are required to cover their heads and everyone should cover their legs and shoulders.