Of course! Visiting Tokushima, Kochi, Ehime, and Kagawa, all situated on Shikoku island in Japan, will offer a delightful cultural and natural experience. Here are some travel tips for your visit:

Best Time to Visit:
The most comfortable time to visit this part of Japan is during the spring (March-May) and autumn (September-November) when temperature and humidity are moderate. Japanese festivals such as Awa Odori in Tokushima (August) and Yosakoi in Kochi (August) are also attractive times to visit.

Route and Accessibility:
The main international gateway to Shikoku is via flights landing in either Osaka or Tokyo. From there, a variety of transportation options including trains, buses, and ferries are available. The most recommended way is the train system, as Shikoku is connected with the rest of Japan through an extensive rail network. The Shikoku Railway Company (JR Shikoku) offers a JR Shikoku Rail Pass which makes travel within Shikoku convenient and cost-effective.

Altitude and Acclimatization:
Shikoku has generally a low altitude, so altitude sickness won't be an issue. However, the island is rather hilly and involves a lot of walking, especially if you plan to participate in the Shikoku Pilgrimage trail. Make sure to be physically prepared and to rest when needed.

Accommodation and Booking:
Accommodations range from traditional ryokan inns and minshuku (B&B), to modern hotels and budget-friendly hostels. It's advised to book in advance, especially during peak seasons or if you're planning to visit during a festival.

Clothing and Essentials:
Clothing should be seasonally appropriate. Comfortable shoes are important as there may be a lot of walking involved. If you’re planning on visiting any temples, dressing modestly is recommended.

Health and Safety:
Prioritize your health, and stay hydrated. Japanese weather can often be humid especially during the summer season, so an adequate intake of water is important. Make sure to get travel insurance before your visit.

Local Etiquette and Respect:
Japanese culture values respect deepy. When visiting temples, follow local etiquette such as removing your shoes and not taking pictures where it's prohibited. In addition, learning a few basic Japanese phrases could help in communicating with locals.