Sure! Montevideo, Paysandú, and Durazno are beautiful cities in Uruguay with lots to offer tourists. Here are some travel tips to make your trip smoother and more enjoyable:

Best Time to Visit:
The best time to visit Uruguay is during their summer, from December to March, with temperatures averaging around 22-28°C. However, if you want to avoid the high season crowds, the shoulder months of November and April provide lovely weather as well.

Route and Accessibility:
Starting from Montevideo, you can reach both Paysandú and Durazno by bus or car. The roads are well-maintained and accessible. There are regular buses to both cities from Montevideo's Tres Cruces bus terminal.

Altitude and Acclimatization:
Uruguay is generally flat, so altitude and acclimatization should not pose any issues.

Accommodation and Booking:
Accommodation options in Montevideo, Paysandú, and Durazno range from luxury hotels to budget hostels. It's recommended to book your accommodation in advance during the peak season (December to March).

Clothing and Essentials:
Uruguay’s weather can be quite varied, so pack layers including light clothing for warm days, and a waterproof jacket for any unexpected rain showers. Don't forget sunscreen and a hat to protect against the strong South American sun.

Health and Safety:
Uruguay is generally a safe country but use your common sense especially in crowded places and at night. Drink bottled water and follow basic hygiene practices. If you plan to rent a car, make sure to follow the local traffic rules.

Local Etiquette and Respect:
Uruguayans are generally polite, friendly, and respectful. While visiting, respect local customs and traditions, try to speak a little Spanish and enjoy 'mate', the national drink. Dress modestly when attending religious or formal events.

Remember that Uruguay has a very relaxed pace of life, which is an integral part of their culture, so take the opportunity to relax and enjoy your trip!